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What are OPIOIDS and OPIATES?
Opiates are potent analgesic (pain relieving) drugs. They are often prescribed to relieve acute or chronic pain and pain from serious illnesses. They can also be used to suppress a chronic cough and diarrhea. Opiates or opioids can be broken down into several categories:
- Natural opiates
- Semi-synthetic opiates
- Fully-synthetic opiates
- Endogenous opioid peptides
What is the Difference between Opioids vs. Opiates?
Finding differences between opioids and opiates can be quite daunting. Although the two terms do have distinctions, they are often interchangeable. Opium, found in poppy plants, is used to make natural opiates. Morphine, codeine, and opium are a few examples of natural opiates.
Opiates can also be found naturally in the human body in the form of endogenous opioid peptides. These include endorphins and dynorphins.
Opioids are synthetic or partly synthetic. They are manufactured through chemical synthesis rather than derived from the poppy plant. Semi-synthetic opioids include buprenorphine, hydrocodone, oxycodone, hydromorphone, and oxymorphone. Fully synthetic opioids include Fentanyl, Tramadol, and Methadone.
Both natural opiates and their synthetic counterparts act similarly in the human body by binding to certain opioid receptors in the central nervous system and in other tissues.
What is Opioids used for?
Opiates have been used to treat many different types of pain; most noteworthy, for their essential role in managing long-term chronic pain in those who are terminally ill with conditions such as cancer.
In recent years, prescriptions for opiate painkillers have increased, especially for non-malignant, chronic pain. Also, for the following uses:
- Analgesic (to combat pain)
- Terminal illness
- Diabetic neuropathy
- Serious trauma or injury
- Cough suppressant
- Drug detoxification (methadone and buprenorphine)
As with any medication, taking an opiate medication can cause any number of side effects to develop. To avoid serious side effects, they should be taken exactly as prescribed. Altering the dose in any way can be dangerous or even fatal.
Common side-effects include:
- Severe constipation
- Loss of appetite
- Tingling or redness of the skin
- Blurred vision
Signs of an allergic reaction include:
- Difficulty breathing
- Closing of the throat
- Hives or swelling of the lips, face, tongue or throat
Any of these serious side effects should prompt a visit to the emergency room.
Warning and Risks
Opiates are also part of a successful pain management plan, but specific risks are involved. These can include addiction, withdrawal upon cessation of use and overdose. Opioids are controlled substances in the United States that contain heroin and some prescription painkillers such as Actiq, Dilaudid, Vicodin, OxyContin, and Percocet.
Opiates can affect response and reaction times. As a result, patients should avoid operating heavy machinery or driving until they know how they’ll respond to the medication. Women who become pregnant may be encouraged to prevent prescription painkillers because of possible complications.
Dangerous side effects can develop for patients who combine opiates with alcohol, other narcotics, tranquilizers or some sleeping medications. It’s important for patients to check their food and beverage labels to make sure alcohol is not an ingredient. Opiates are central nervous system depressants. Taking them with other substances can cause serious, even fatal effects.
Opiates also act directly on the respiratory center in the brainstem, where they cause a slowdown in activity. This condition can result in a decrease in breathing rate. Excessive amounts of opiates, like heroin, can cause the respiratory centers to shut down breathing altogether. When someone overdoses on heroin, it is the action of heroin in the brain stem respiratory centers that can cause the person to stop breathing and die.
Feelings of pain occur when specialized nerves are activated by trauma, either through injury or illness. You can find these specialized nerves throughout the body, and they carry the pain message into the spinal cord. The pain message passes to other neurons, which also results in brain response.
Opiates help to relieve pain by acting in both the spinal cord and brain. At the spinal cord, opioids interfere with the transmission of the pain messages between neurons and prevent them from reaching the brain. This process is known as analgesia.
Opiates also act in the brain to help relieve pain. There are several areas involved in interpreting and responding to pain messages. They allow a person to know he or she is experiencing pain and that it is unpleasant. Opiates working in these regions don’t block the pain messages, rather, they change the subjective experience of the pain. As a result, patients might feel a full discomfort relieve.
How do you build a Tolerance to Opioids?
A person who takes opiates for a long enough period will likely develop opioid (opiate) tolerance. The body adapts to the presence of the drug, resulting in a decrease in its effectiveness over time.
Tolerance is a desensitization of the opioid receptors leading to an increased feeling of pain and a need for a higher dose. Another cause of tolerance is when the opiate receptors have been internalized by the cell itself; this is called endocytosis, a condition marked by a decrease in opioid binding sites that are available to provide pain relief.
Long-term opiate use can be dangerous because it can lead to dependence, addiction, and overdose. Opiate-induced tolerance can underlie all of these issues because as tolerance develops, patients need increasingly higher doses of the drug to achieve analgesia. A person who is suffering from chronic pain just wants relief. They may not think about the effects of long-term opioid use and potential risks.
Another condition that may overlap with opioid tolerance is opioid-induced hyperalgesia. Prolonged use of opioids leads to a paradoxical increase in pain despite increases in drug dosage.
Increased sensitivity to pain can happen to anyone taking any dosage of an opioid. It’s important that patients not increase their dosage without talking to a doctor.
Symptoms of ADDICTION and OVERDOSE
Opioids are unrivaled when it comes to pain management, but many risks accompany them. These narcotic drugs can be habit-forming and may lead to physical and/or psychological dependence. These are medications for moderate to moderately severe pain, or when discomfort that persists around the clock.
The compulsive use of opiates or any purpose outside the label’s instructions can constitute abuse. Most people don’t set out to become addicted to their medication. In fact, most people become “accidental addicts” after taking prescription medication for a legitimate condition.
Oxycodone, Percocet, and Fentanyl are among the most prescribed drugs and also among the most abused. Once the regular use has caused a tolerance, the drug becomes ineffective at producing the intended effects. At this point, many people decide to escalate their use.
Other forms of abuse include breaking, crushing or otherwise disturbing the medication to cause rapid release of the medicine. Abuse can damage your health, ability to function normally in everyday life and ruin careers and relationships
What is an Opioid Addiction?
Opiate addiction is a central nervous system disorder, caused by continuous opiate intake. Opiates elicit their powerful effects by activating opiate receptors throughout the brain and body. Two significant results produced by opioids are the pleasure (or reward) effects and pain relief. The rush of pleasure and/or relief from pain is so strong and powerful; it can lead to opiate abuse and addiction.
The brain itself produces substances known as endorphins (the body’s natural painkiller) that activate the opiate receptors. They are involved in respiration, nausea, vomiting, pain modulation and hormonal regulation. After prolonged opiate use, the nerve cells in the brain, which would otherwise produce these endogenous opiates, cease to function normally. The body stops producing endorphins because it is receiving opiates instead. The degeneration of these nerve cells causes a physical dependency on an external supply of opiates. Abrupt or sudden abstinence from opiates induces yet another traumatic disorder – withdrawal syndrome.
How do Opioids and Opiates Affect your Brain?
Findings from animal research indicate that, like cocaine and other abused drugs, opiates can also activate the brain’s reward system. When a person injects, sniffs or orally ingests heroin (or morphine), the drug travels quickly to the brain through the bloodstream.
Because of its chemical structure, heroin penetrates the brain more quickly than other opiates on the list, which is probably why many addicts prefer heroin.
Once in the brain, the heroin is rapidly converted to morphine, which then activates opiate receptors located in the VTA, nucleus accumbens and cerebral cortex. Once the pleasure circuit is activated, great amounts of dopamine are released within the nucleus accumbens. This phenomenon causes an intense euphoria, or rush, that lasts only briefly while relaxation and contented state can last longer. This excessive release of dopamine and stimulation of the reward system can lead to opiate abuse and addiction.
Opioid Addiction VS Dependence
Although sometimes used interchangeably, the terms “addiction” and “dependency” describes two separate things. Opiate dependence does not always entail opiate addiction.
Compiling the research from The National Institute of Health, The American Academy of Pain Medicine, the American Pain Society and the American Society of Addiction Medicine, one can create a general definition for each:
Addiction: Addiction is a primary, chronic, neurobiological disease. Genetic, psychosocial and environmental factors influence its development and manifestations. Opiate addiction is characterized by behaviors that include: impaired control over drug use, compulsive use, craving and continued use despite adverse and dangerous consequences.
Physical dependence: Physical dependence is a state of adaptation that is manifested by withdrawal syndrome. It can be produced by abrupt cessation, rapid dose reduction, decreasing the blood level of the drug and/or the administration of an antagonist. Physical drug dependence means a person needs the substance to function and can have intense cravings.
Opiate addiction is a disorder often caused by an untreated condition. It is known to have a strong potential for relapse because if the real issue does not receive the adequate treatment, a person may fall back into old patterns of drug use and abuse. Opiates are extremely potent drugs with a particularly high relapse rate. Strong cravings and withdrawal symptoms can trigger relapse when not well managed, even after a period of abstinence.
Symptoms of an Opioid Overdose
One should always be cautious when using prescription medications. Warnings and precautions are available on the label or through your pharmacist. Labels often spell out risks, including overdose, and give guidelines for avoiding further risks. Opiate overdose can be fatal, so it’s important to take these medications exactly as prescribed. Patients who overdose on opiates almost always do so accidentally after one escalates use due to tolerance to the drug.
However, overdose can also be intentional for those using it recreationally to achieve a state of euphoria. The risk of fatal overdose is high among this group, especially those people who combine opioids with other substances to heighten effects.
Opioids are central nervous system depressants. They slow respiration, which can lead to serious health complications including cardiac arrest, coma, and death. All users must be aware of overdose symptoms and how to obtain emergency medical assistance.
Symptoms of overdose can include:
- Feeling of cold
- Clammy skin
- Slowed heart rate
- Difficulty breathing
If the overdose is recent, doctors may induce vomiting, pump the stomach or use activated charcoal so the body doesn’t absorb the drug. An antidote may also be given to counteract the effects of an opioid overdose.
Opioid Withdrawal Symptoms and Risks
One of the most challenging aspects of recovery from opiate addiction is the withdrawal process. Many of our patients want to know what to expect from the opiate withdrawal process. However, no two people have the same withdrawal experience. The timeline for opiate withdrawal depends on a variety of factors and differs between individuals. That is why effective treatments for opiate addiction cannot take a “one size fits all” approach. Understanding the typical symptoms of opiate withdrawal can help you make informed decisions about your treatment.
Drug addiction does not develop overnight. Opiates — whether heroin or prescription painkillers — exert their effects by crossing the blood-brain barrier and acting on specific brain areas. The opiate molecules bind to particular receptors in the limbic system of the brain, which is responsible for processing rewards and emotional information. When these receptors are activated, they trigger the “rush” or euphoric sensations experienced by opiate users.
Over time, however, the brain becomes numb to the effects of opiates and tolerance is built. It takes more and more of the drug to achieve the same effect. When the drug is no longer present, and the body does not get its usual dose, the result is a collection of physical and psychological symptoms.
Opiate withdrawal symptoms typically start within a few hours of the drug leaving the bloodstream. They peak between 5 and 10 days. The severity and duration of the opiate withdrawal symptoms can depend on the length of opiate dependence, dosage, metabolism, the drug of choice and other factors.
Most people have no residual symptoms after a few weeks, although some people have reported experiencing a post-acute withdrawal syndrome (PAWS) that lasts up to a few months. Many individuals in the recovery community have commonly described PAWS. However, the Diagnostic and Statistical Manual of Mental Health Disorders, or any other significant medical association, do not recognize it.
Going “cold turkey” can be dangerous for some opiate users. Patients run the risk of severe dehydration or elevated blood pressure. Furthermore, opiate withdrawal can cause heart irregularities that may be dangerous for patients with certain chronic medical conditions. Professional medical attention is suggested to keep one safe during the opiate withdrawal process. For example, medical detox protocols help remove opiates from your system and safely manage withdrawal symptoms.
Perhaps one of the most prominent disadvantages of going “cold turkey” is the high likelihood of relapse, and due to the extreme discomfort of withdrawal, some might not even complete the process. Professional medical detox is more likely to result in a positive, safe, and effective way to obtain an opiate-free life. The Waismann Method ® located exclusively in Southern California has successfully treated thousands of patients and medically assisted them in overcoming opiate withdrawal symptoms.
Opioid Detox an Treatment Options
A person who has developed a physical and/or psychological dependence on an opiate (narcotic) medication will need a professional detox to recover safely. Examples of these opioids include Oxycodone, Hydrocodone, Fentanyl, Methadone, Morphine, Suboxone, and heroin.
Opioid addiction has become a tremendous problem in the U.S. due to several factors including the high number of prescriptions available. Opioids have become increasingly easier to obtain, both among patients seeking pain relief, as well as recreational users. Detox is the first step in any responsible recovery program. It can be an intense process but one that can be medically managed by professionals. This helps to ensure safety and maximize your chance of long-term recovery
Waismann Method® of Rapid Detox and Opioid Medical Detoxification
Opiate abuse can lead to addiction, which calls for specialized medical detox to ensure safety and success. The Waismann Method offers a renowned rapid detox and a medical opiate detoxification program based on the idea that all patients should receive treatment with the utmost respect, professionalism, and compassion. Our safe, humane treatment for opioid detox can help patients overcome their physical dependence to opioids within days.
Rapid detox procedure is performed in less than two hours and uses intravenous medicine to cleanse the opiates from patients’ receptor sites. Our opiate detox helps to medically manage and overcome the withdrawal symptoms without the use of other opiates. Patients also take advantage of our exclusive recovery center, Domus Retreat, for a few days. The Waismann treatment is unique and thorough and is design for those who seek the best and most advanced form of medical opiate detox available. Patients have options of 5, 7, 10 or 14 days program. It is all-inclusive, and around the clock care is available. From the extensive pre-treatment assessment, throughout the detoxification with our multi-board certified anesthesiologist and finally at our private recovery center.
List of Opioids and Opiates
Click on a drug from the list below for more information