Vicoprofen is the brand name for the combination of hydrocodone and ibuprofen and is considered a short-term solution for severe pain. Hydrocodone is a narcotic pain reliever and ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID). It reduces hormones that cause inflammation and pain in the body. Vicoprofen comes in tablet form with 7.5 mg of hydrocodone bitartrate, a semi-synthetic opioid analgesic, and 200 mg of ibuprofen. Inactive ingredients in Vicoprofen include corn starch, colloidal silicone dioxide, croscarmellose sodium, hypromellose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, polysorbate 80 and titanium dioxide.

The drug was approved by the Food and Drug Administration in 1997 and is available in generic form. It is not recommended for patients to take more than five tablets per day, and Vicoprofen is supposed to be taken every 4-6 hours.

Vicoprofen Side Effects

One of the most common side effects of opiate use is constipation. In addition, side effects reported include: abdominal pain, flu-like symptoms, fever, headache, palpitations, anxiety, confusion, dizziness, sleep problems, nervousness, diarrhea, dry mouth, dyspepsia, gas, edema, hiccups, rhinitis, sweating, frequent urination, allergic reaction, abnormal dreams, decreased libido, depression, euphoria, mood changes, tremors and weight loss.

Possible Drug Interactions

Patients taking Vicoprofen and ACE-inhibitors should be aware of a possible interaction. Some reports indicate that NSAID medications could diminish the antihypertensive effect of ACE-inhibitors. Using Vicoprofen with Monoamine Oxidase Inhibitors (MAOIs) or tricyclic antidepressants may increase the effect of either. MAOIs can reportedly intensify the effects of some opioid drugs, causing confusion, anxiety, depression, respiratory depression and coma.

The central nervous system could become depressed if patients use Vicoprofen with other opioids, antipsychotics, antihistamines, alcohol or other antianxiety medications. Vicoprofen and other NSAIDs can lead to serious gastrointestinal conditions including bleeding, inflammation, ulcers and perforation of the stomach, small intestine or large intestine. People taking Vicoprofen should use caution when performing tasks that require alertness, such as driving.

Vicoprofen’s Main Active Ingredient

Hydrocodone preparations are marketed under names including Vicodin, Lorcet, Lortab, Norco, Anexsia, Hycodan, Tramadol, Zydone, Tylox, Tussionex and Hycomine. It is a semi-synthetic opioid. The drug, which can be habit-forming, is used as a pain reliever and cough suppressant. Hydrocodone relieves pain by binding to the opioid receptor sites in the brain and spinal cord. It is not available in pure form in the U.S., and is typically found in combination with other drugs including aspirin and ibuprofen. A mixture of hydrocodone and acetaminophen is marketed as Vicodin and Lortab, and hydrocodone and aspirin is marketed as Lortab ASA.

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