fb pixel

Vicodin (Hydrocodone/Acetaminophen): Brand Discontinued, Generic Still Prescribed

Reviewed by Clare Waismann, M-RAS, SUDCC II, Founder of the Waismann Method — April 23, 2026

Medical content last reviewed by Michael H. Lowenstein, M.D., Quadruple Board-Certified Physician and former Medical Director — February 23, 2023

Important Update: The Vicodin Brand Is No Longer Available

The Vicodin brand name has been discontinued in the United States. The generic equivalent — hydrocodone/acetaminophen, sometimes written as hydrocodone/APAP remains widely prescribed. If you or a family member was prescribed “Vicodin” in recent years, you most likely received the generic version.

Vicodin was for decades one of the most recognizable opioid pain medications in America, prescribed to millions of patients and referenced widely in popular culture. Its original formulations were discontinued by the brand manufacturer in 2012 following the FDA’s decision to limit acetaminophen in prescription combination products to 325 mg per dosage unit. The 2014 reclassification of hydrocodone combination products from Schedule III to the more restrictive Schedule II further reshaped how the medication is prescribed today. Other brand-name versions of the same drug, including: Norco, Lortab, Lorcet, and Hycet, which have also been discontinued. Only generic hydrocodone/acetaminophen remains on the market.

What Was Vicodin?

Vicodin combined two active ingredients:

  • Hydrocodone bitartrate — a semi-synthetic opioid that binds to opioid receptors in the central nervous system to reduce pain perception
  • Acetaminophen — a non-opioid pain reliever that enhances analgesic effect but carries liver toxicity risk at high doses

Vicodin was originally available in multiple strengths, including Vicodin ES and Vicodin HP, with varying hydrocodone and acetaminophen combinations. After the FDA’s 2011 acetaminophen limit, these formulations were reformulated or discontinued. Generic equivalents are now prescribed in standardized strengths of 5 mg, 7.5 mg, and 10 mg hydrocodone with 325 mg acetaminophen.

Because the Active Ingredients Are Unchanged

The generic hydrocodone/acetaminophen available today has the same active ingredients, the same clinical effects, the same risks of dependence and liver toxicity, and the same withdrawal profile that Vicodin did. Everything that was clinically true of Vicodin remains true of the generic.

For comprehensive information on the underlying medication — including pharmacology, dependence and tolerance, withdrawal timeline, treatment approaches, and the full clinical reference — see our main page:

Hydrocodone and Acetaminophen: Complete Clinical Reference

For information on other brand names of the same combination, see Norco.

If You Need Help Today

The Waismann Method no longer accepts patients. For current treatment:

  • SAMHSA’s National Helpline1-800-662-HELP (4357) — free, confidential, 24/7
  • FindTreatment.gov — official U.S. government treatment locator
  • Emergency or overdose: Call 911 immediately. Administer naloxone (Narcan) if available.

Disclaimer: This information is provided for general educational purposes and does not constitute medical advice. Always consult a qualified healthcare provider regarding any medical condition or treatment decision.

Frequently Asked Questions

Is Vicodin still available in the United States?

No. The Vicodin brand was discontinued in the United States. The generic equivalent, hydrocodone/acetaminophen (also written as hydrocodone/APAP), remains widely prescribed and has the same active ingredients in the same strengths.

Why was Vicodin discontinued?

The original Vicodin formulations were phased out primarily due to the FDA’s 2011 requirement limiting acetaminophen in prescription combination products to 325 mg per dosage unit, which was implemented to reduce the risk of liver damage from accidental overdose. The 2014 reclassification of hydrocodone combination products from Schedule III to Schedule II further changed how the medication is prescribed and distributed.

What is the generic version of Vicodin called?

The generic is called hydrocodone and acetaminophen, sometimes written as hydrocodone/acetaminophen or hydrocodone/APAP. It contains the same active ingredients as Vicodin and is prescribed in strengths of 5 mg, 7.5 mg, and 10 mg hydrocodone combined with 325 mg acetaminophen. For comprehensive clinical information, see our Hydrocodone and Acetaminophen reference page.

Is the generic hydrocodone/acetaminophen the same as Vicodin?

Clinically, yes. The generic has the same active ingredients, the same pain-relieving effects, the same risks of dependence and liver toxicity, and the same withdrawal profile as Vicodin. Inactive ingredients such as binders or fillers may differ between manufacturers, but the clinically relevant components are identical.

Sources:

Latest Information and News on Opioids