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Vicoprofen is the brand name for the combination of hydrocodone and ibuprofen and is considered a short-term solution for severe pain. Hydrocodone is a narcotic pain reliever, and ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID). It reduces hormones that cause inflammation and pain in the body. Vicoprofen comes in tablet form with 7.5 mg of hydrocodone bitartrate, a semi-synthetic opioid analgesic, and 200 mg of ibuprofen. Inactive ingredients in Vicoprofen include corn starch, colloidal silicon dioxide, croscarmellose sodium, hypromellose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, polysorbate 80, and titanium dioxide.

The drug was approved by the Food and Drug Administration in 1997 and is available in generic form. It is not recommended for patients to take more than five tablets per day, and it is recommended to be taken every 4-6 hours. Each patient’s initial response to Vicoprofen must be assessed at the lowest effective dose and adjusted per individual needs, never exceeding the recommended daily dose.

Vicoprofen’s Main Active Ingredient

Vicoprofen consists of two active ingredients that deliver pain relief; however, they work quite differently. These components are hydrocodone and ibuprofen.

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Vicoprofen Side Effects

One of the most common side effects of opiate use is constipation.

Besides, side effects reported include abdominal pain, flu-like symptoms, fever, headache, palpitations, anxiety, confusion, dizziness, sleep problems, nervousness, diarrhea, dry mouth, dyspepsia, gas, edema, hiccups, rhinitis, sweating, frequent urination, allergic reaction, abnormal dreams, decreased libido, depression, euphoria, mood changes, tremors, and weight loss.

Vicoprofen is not recommended for renal disease patients as it may lead to renal injury or renal toxicity. For patients with heart failure and fluid retention, Vicoprofen should be used with caution.

Vicoprofen may raise the risk of heart attack or stroke; it may happen as soon as within the first weeks of taking medicine and may become greater with long-term use and higher doses. Vicoprofen may not be used before or after bypass surgery.

Opioid drugs like Vicoprofen may lead to dependence if taken regularly or long-term. Changing the dose or stopping the medication altogether may cause a withdrawal risk or other serious issues. Following your doctor’s instructions is of the greatest importance. If you experience more pain, sudden mood changes, thoughts of suicide – talk to your doctor!

Possible Drug Interactions

Concomitant administration of Vicoprofen and aspirin is not generally recommended because of the potential of increased adverse effects. Use of Vicoprofen with CNS depressants, such as alcohol, muscle relaxants, anxiolytics, non-benzodiazepine sedatives, opioids, general anesthetics, and benzodiazepines, may cause shallow breathing, profound sedation, coma, or death.

Patients taking Vicoprofen and ACE-inhibitors should be aware of a possible interaction. Some reports indicate that NSAID medications could diminish the antihypertensive effect of ACE-inhibitors. Using Vicoprofen with Monoamine Oxidase Inhibitors (MAOIs) or tricyclic antidepressants may increase the effect of either. MAOIs can reportedly intensify some opioid drugs’ effects, causing confusion, anxiety, depression, respiratory depression, and coma.

The central nervous system could become depressed if patients use Vicoprofen with other opioids, antipsychotics, antihistamines, alcohol, or other antianxiety medications. Vicoprofen and other NSAIDs can lead to serious gastrointestinal conditions, including bleeding, inflammation, ulcers, and perforation of the stomach, small intestine, or large intestine. People taking Vicoprofen should use caution when performing tasks that require alertness, such as driving.

Patients have to inform their healthcare professional if they have ever experienced any of the following:

  • High Blood Pressure
  • Head Injury
  • Problems with breathing, liver, kidney, gallbladder, thyroid, adrenal gland, pancreas
  • Stomach Ulcer
  • Taken Sedatives

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